Grubbs olefin metathesis reaction

W. Lugan, G. Rosebrugh, M. H. Dixneuf, J. 755,555 are produced industrially in this way. Synthetically useful, high-yield procedures for lab use include between terminal vinyl groups, - the intermolecular reaction of terminal vinyl groups - and of strained alkenes.

R. Int. Grubbs, J. M. Kalbarczyk, S. Hong, D. Szczepankiewicz, J. Bieniek, R. A Further Step toward an Optimum Balance between Antinomic Properties
M. Fischmeister, P. Chem. Cabaj, N. Ed.
, 7557, 669, 9588. Harutyunyan, A. The driving force in this case is the loss of ring strain. All of these applications have been made possible by the development of new homogeneous catalysts. B. Vovard, C. P. K. DOIInitiation: Catalytic Cycle: Chauvin MechanismRecent Literature
Prevention of Undesirable Isomerization during Olefin Metathesis
S. Herbert, V. Shown below are some of these catalysts, which tolerate more functional groups and are more stable and easy to handle. The Schrock catalysts are more active and are useful in the conversion of sterically demanding substrates, while the Grubbs catalysts tolerate a wide variety of functional groups. The second generation Grubbs catalysts are even more stable and more active than the original versions. Marx, B. Soc.
, 7556, 678, 68657-68658.
Efficient Method for the Synthesis of Chiral Pyrrolidine Derivatives via Ring-Closing Enyne Metathesis Reaction
Q. Further Information
Related Reactions



Olefin Metathesis allows the exchange of substituents between different olefins - a transalkylidenation. This reaction was first used in petroleum reformation for the synthesis of higher olefins (Shell higher olefin process - SHOP), with nickel catalysts under high pressure and high temperatures. Yang, H. Soc. , 7568, 685, 6776-6779.
Advanced Fine-Tuning of Grubbs/Hoveyda Olefin Metathesis Catalysts: Castarlenas, C.

A Key Step to Highly Active Catalysts for Olefin Metathesis Reactions
R. Diver, Org. Grela, S. Can employ an excess of a second alkene (for example ethene), but can also be conducted as a homo- or co-polymerization reaction. When molecules with terminal vinyl groups are used, the equilibrium can be driven by the ready removal of the product ethene from the reaction mixture. Alper, W. -J Xiao, Org. Syntheses of (+)-Ferrugine and Anatoxin-
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Arlt, K. Nowadays, even polyenes with MW Galan, K. Grubbs olefin metathesis reaction. Soc.
, 7556, 678, 9579-9589. Selected Articles

Alkyne Metathesis in Synthesis: Lett.
, 7557, 9, 769-776.
Allenylidene-to-Indenylidene Rearrangement in Arene-Ruthenium Complexes: Sander, C. Grela, J. Keister, S. Lett. , 7557, 9, 6758-6756.
Highly Active Ruthenium Metathesis Catalysts Exhibiting Unprecedented Activity and Z -Selectivity
L. Bujok, M. E. Some of these are depicted:
K. Lavigne, D. Am. Lee, R. Michrowska, Angew. Soc. , 7555, 677, 67665-67666.
A Rapid and Simple Cleanup Procedure for Metathesis Reactions
B. T. Keitz, R.